Interaction between pathogenic proteins in neurodegenerative disorders
نویسندگان
چکیده
منابع مشابه
Interaction between pathogenic proteins in neurodegenerative disorders
The misfolding and progressive aggregation of specific proteins in selective regions of the nervous system is a seminal occurrence in many neurodegenerative disorders, and the interaction between pathological/toxic proteins to cause neurodegeneration is a hot topic of current neuroscience research. Despite clinical, genetic and experimental differences, increasing evidence indicates considerabl...
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With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is structurally corrupted by its misfolded conformer. The latest research indicates that, once formed,...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2012
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2011.01507.x